Describe schizophrenia in terms of negative symptoms and the postulated underlying neuronal circuitry responsible for negative symptoms. How do antipsychotics cause prolactin elevation and what are the consequences of elevated prolactin levels? Can this be treated without cessation of antipsychotic therapy? If so, how? What is the link between a conventional antipsychotic and the development of neuroleptic-extrapyramidal symptoms and tardive dyskinesia? 

Describe schizophrenia in terms of negative symptoms and the postulated underlying neuronal circuitry responsible for negative symptoms. How do antipsychotics cause prolactin elevation and what are the consequences of elevated prolactin levels? Can this be treated without cessation of antipsychotic therapy? If so, how? What is the link between a conventional antipsychotic and the development of neuroleptic-extrapyramidal symptoms and tardive dyskinesia? 

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