Write a mini-essay using Systemic Lupus Erythematosus (SLE) as a model disease to describe self-tolerance and failure in self-tolerance. Include how peripheral and central tolerance is established in B cells and T cells. You should also include the pathogenesis of this disease, symptoms and signs and the prognosis.
The mini essay is expected to be concise, and the topic covered in a focused, thorough and accurate manner. It should be at least 600 words in length. Your essay must be formatted with 1″ margins,1 1/2 line spacing,12 point easy-to-read font;include a proper heading at the top. Your essay should begin with a clear introduction and must also have a concluding paragraph.
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