Upstream and Downstream Processing

Upstream and Downstream Processing

Link here –> World Markets for Fermentation Ingredients – Reportlinker
Review

Discussion:
After reviewing the above and the attached material for this week, please
discuss three of
the bullet points below in minimum three paragraph each (550 words total)

Bioreactor design is a critical consideration in optimizing
manufacturing. Describe the components and design considerations of a
modern commercial fermenter. If you company was interested in producing
several tons of L-Glutamate from C. glutamicium each year, what kind of
bioreactor would you recommend? Explain your recommendation. In
general, what would you expect to see reported as a trend for commercial
bioreactors IF you had access to the full report
on “World Markets for Fermentation Ingredients – Reportlinker
Review”
Describe current approaches used for downstream separation and
concentration of bioreactor products. If your company is manufacturing
terpenoids from yeast in the bioreactor, what would be your choice of
separation and concentration technologies? Explain your reasoning. In
general, what would you expect to see reported as a trend for downstream
separation and concentration IF you had access to the full
report on “World Markets for Fermentation Ingredients –
Reportlinker Review”
Describe current approaches used for purification and
formulation of biological products. If your company is
manufacturing humanized antibodies from CHO cells in the
bioreactor, what would be your choice of separation and concentration
technologies? Explain your reasoning. In general, what would you
expect to see reported as a trend for antibody separation and
concentration technologies IF you had access to the full
report on “World Markets for Fermentation Ingredients –
Reportlinker Review”. If nothing, why not?
What are some of the important design criteria in process
development? Why does the relative importance of these criteria change
according to what is being produced? How would you maximize productivity
of a biomanufacturing process? Describe the relationship between purity,
yield and volume. For insulin used to manage type I diabetes, what are
current yields and purity targets? [hint: do so independent research]
What are some of the important parameters than need to be monitored
and controlled during production? What are some of the tools that can be
used to measure these parameters; what are some of the newer ones? How do
you think one can prioritize among the many parameters to be
optimized? In general, what would you expect to see reported as
a trend for monitoring equipment and process improvements IF
you had access to the full report on “World Markets for
Fermentation Ingredients – Reportlinker Review”.
Scaling up from a 1L bench-top bioreactor to a 1000L production
bioreactor can be challenging. What are some of the key technical and
financial considerations in scaling up a process? Don’t just state
the obvious- this needs information from research and readings for a good
post!

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