What role do you think the environment and genetics play on biological clocks and their entrainment?

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Could studying all night cause a disturbance in rhythmic behavior? It is common practice for medical student interns to work 24- to 36-hour shifts. How does this affect their performance or judgment? Is there a relationship between sleep deprivation and the performance of complex and/or simple tasks? What role do you think the environment and genetics play on biological clocks and their entrainment?

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