Best Writer

The PTEN gene is deleted in multiple types of advanced human cancers. The resulting loss of the PTEN protein contributes to the uncontrolled growth of cells. Indeed, cells lacking PTEN have elevated levels PI(3,4,5)P3 and PKB activity. Because PKB exerts an anti-apoptotic effect, loss of PTEN reduces the programmed cell death that is the normal fate of many cells. In certain cells, such as neuronal stem cells, absence of PTEN not only prevents apoptosis, but also leads to stimulation of cell cycle progression and an enhanced rate of cell proliferation. Knockout mice lacking PTEN have big brains with an excess numbers of neurons, attesting to PTEN’s importance in the control of normal development.

Question: What is the detailed step-by-step PTEN signaling pathway? Discuss and support your analysis with cited references and data from published scientific articles.

Technical Writing Requirements:
-Number of Pages: 6 minimum and 8 maximum.
-Line Spacing: single spacing
-Font size: 11 points minimum and 12 points maximum.
-Font style: Arial or Times New Roman
-Left and Right Margins: 0.75 inch each.
-Top and Bottom Margins: 1 inch each.

Title:
Provide a title for your lab report.
Author:
Your full name and mentor(s).
Significance:
Detailed paragraph (i.e. multiple sentences describing the summary of previously published research.
Introduction:
Provide detailed background information on your research topic while citing relevant references (scientific publications only, about 15 citations). Briefly state the major question of lab project, reiterate your hypothesized pathway, and describe how you will go about addressing the hypothesis. This section will involve multiple paragraphs.
Materials and Methods:
Write the details of your reviewed literature, data analysis, all the resources and databases used in the meta-analysis.
Results:
Provide brief description of the data.
Discussion:
Discuss the results of your review especially in relation to your hypothesized pathway.
Conclusion:
Provide a summary conclusion of your findings.
Acknowledgement:
Provide any support in terms of personnel, resources, and funds.
References:
Provide a formatted list of your curated citations relevant to your research as a bibliography (scientific publications only, greater than 15 citations) .

Initial Post For the initial post, respond to one of the following options, and label the beginning of your post indicating either Option 1 or Option 2:
Option 1: The framers of the Constitution were concerned that everyday citizens would not be able to understand or comprehend the makings of our government. They felt that everyday citizens were uninformed and did not care what was going on in our government. Even today we see where citizens are interested in government affairs seemingly only if our country is in turmoil such as unemployment, recessions, civil unrest, etc. Do you agree with this assessment? Are we uninformed? Do we wait till a crisis happens to voice our opinions?
Option 2: Many experts see the media as biased and more like infotainment. In fact, many people have turned to social networks as an outlet for news instead of CBS, NBC, FOX, CNN and other news stations. Do you see this as an issue? Do you see the news as biased or unbiased? Should there be more restrictions on the news stations?
Be sure to make connections between your ideas and conclusions and the research, concepts, terms, and theory we are discussing this week.
Follow-Up Post Respond to at least one peer. Further the dialogue by providing more information and clarification. Minimum of 1 scholarly source which can include your textbook or assigned readings or may be from your additional scholarly research.
Writing Requirements
Minimum of 2 posts (1 initial & 1 follow-up)
Minimum of 2 sources cited (assigned readings/online lessons and an outside source) for your Initial Post, and 1 scholarly source for your Follow-Up Post.
APA format for in-text citations and list of references

Discuss about the Heart of addiction a biblical perspective book review by Mark E. Shaw.

** Food additive: Blue #1**
You must use a minimum of two
professional nutrition journals that were written over the past five years (2015-2021)
to support your research. The report must be a minimum of two pages long, typed,
and double spaced (maximum three pages) addressing the below criteria. Final
assignment must be submitted under the assignment tab in Blackboard.
1.
Identify a food item/product containing your
assigned food additive. Provide a detailed description of the food additive and
identify a product the additive was or is currently used in. Attach a copy of the food label. The label is
not part of the two- page write-up but must be attached to the paper on
Blackboard.

2.
Provide a detailed summary regarding the purpose
of why the food additive is utilized in the product you selected.

3.
A) Categorize your selected food additive to
match one of the below Category criteria.

B) Information Selection- use current professional research
to support your findings. This section
should be no more than 2 pages and include a summary of information from a
minimum of 2 research articles obtained from a professional journal over the
past 5 years.

C) Provide an analysis of the information collected
and clearly draw appropriate conclusions supported by evidence.

Categories:
·
Safe- appears to be safe
·
Cut Back- Not toxic, but large amounts may be
unsafe or promote bad nutrition.
·
Avoid- unsafe in amounts consumed or very poorly
tested.
·
Caution- may pose a risk and needs to be better
tested.
·
Certain People Should Avoid- May trigger an
acute, allergic reaction, intolerance or aggravate certain health issues.

4. Content
write-up –must be interesting, clear and use expressive vocabulary. No spelling
or grammatical errors noted. Documentation of findings is clearly stated.

Appropriately cite your work and include an
annotated bibliography in MLA format.

This semester you are required to write a paper that considers the history of American citizenship & immigration. Your paper should address the following questions:
Historically, how has the United States defined and establish citizenship? How has this changed over time? Have there been restrictions placed on who can become a citizen in the United States? If so, explain the restrictions–who did they applied to?
Define “race” and “ethnicity.” How have immigrants’ race and/or ethnicity impacted their immigration experience to the US? What are the US’ philosophies of race and ethnicity and how have they changed over time?
How did the US treat America’s first non-citizens, Africans? Historically, how has the US handled African American citizenship? Has this changed over time?
How did the US handle citizenship for other immigrant groups that we discussed in this course?
You must use these questions and create a thesis statement that introduces your paper and your point of view. Don’t think of this assignment as address 4 separate prompts—you should find a way to make this a cohesive paper.
You must address Forced African immigration as well as 2 other groups of your choosing that we discuss this semester in class.
This assignment will be turned in, in 4 different steps.
Step IV: Final Paper (220)
This assignment requires students to turn in the final draft of their paper. This rough draft must include: A strong thesis statement, an introductory paragraph, body paragraphs, and a strong conclusion paragraph.
You should present and answer “big questions” about race and ethnicity in American history in a refined and professional manner using specific information from class as evidence for your arguments and observations. You should also show that you have taken feedback from the previous writing assignments and that you made revisions when necessary. This is your final draft so we are looking for something close to perfection. This is your time to shine!
RUBRIC
Guidelines & Point Distribution (/220 points)
Paper has a strong thesis statement (/40 points)
Paper has a strong introductory paragraph that introduces material effectively (/20 points)
Paper has well written and thoughtful body paragraphs (/50 points)
Paper has a strong and thoughtful conclusion (/15)
Student has taken edits seriously from previous assignments and made revisions to reflect those edits (/25 points)
Grammar is correct and tone is professional. The draft is free from major grammatical errors and the tone is formal in nature (/20 points)
Paper presents clear ideas and supports them with evidence (/50)
ROUGH DRAFTS:
If you would like feedback/comments on your assignment before you submit them, please send a rough draft to your assigned grader. (Graders will be assigned after drop/add week)
Graders will accept rough drafts of this assignment until April 11 at 11:59pm. If you miss this deadline you should not expect that graders will have enough time to return your rough draft with comments.
Assigned Graders:
DON’T LOSE POINTS:

1500 words are required for this assignment
10-30 words under -10 points
31-75 words under -25 points
More than 75 words under and students can only receive half credit on the assignment
Students may go up to 150 words over with no penalty but going over 150 words will result in -10 points
-50 If you don’t address Forced African Immigration
-30 if you only discuss 1 additional immigrant group
-60 if you fail to discuss 2 additional immigrant groups
Students MUST INCLUDE A WORD COUNT on their paper. If no word count is included students will lose 25 points
More information on Mechanics[1]:
Introduction/Context:
Your introduction provides context to your readers to prepare them for your paper’s argument or purpose. An introduction should begin with discussion of your specific topic (not a broad background overview) and provide just enough context (definitions of key terms, for example) to prepare your readers for your thesis or purpose statement.
Sample Introduction/Context: If the topic of your paper is the link between educational attainment and health, your introduction might do the following: (a) establish the population you are discussing, (b) define key terms such as healthy and well-educated, or (c) justify the discussion of this topic by pointing out a connection to a current problem that your paper will help address.
Thesis Statement:
A thesis or purpose statement should come at the end of your introduction and state clearly and concisely what the purpose or central argument of your paper is. The introduction prepares your reader for this statement, and the rest of the paper follows in support of it.
Sample Thesis Statement: Because of their income deficit (Smith, 2010) and general susceptibility to depression (Jones, 2011), students who drop out of high school before graduation maintain a higher risk for physical and mental health problems later in life.
Background
After the initial introduction, background on your topic often follows. This paragraph or section might include a literature review surveying the current state of knowledge on your topic or simply a historical overview of relevant information. The purpose of this section is to justify your own project or paper by pointing out a gap in the current research which your work will address.
Sample Background: A background section on a paper on education and health might include an overview of recent research in this area, such as research on depression or on decreasing high school graduation rates.
Major & Minor Points
Major points are the building blocks of your paper. Major points build on each other, moving the paper forward and toward its conclusion. Each major point should be a clear claim that relates to the central argument of your paper.
Sample Major Point: Employment and physical health may be a good first major point for this sample paper. Here, a student might discuss how dropping out of high school often leads to fewer employment opportunities, and those employment opportunities that are available tend to be correlated with poor work environments and low pay.
Minor points are subtopics within your major points. Minor points develop the nuances of your major points but may not be significant enough to warrant extended attention on their own. These may come in the form of statistics, examples from your sources, or supporting ideas.
Sample Minor Point: A sample minor point of the previous major point (employment and physical health) might address worker injury or the frequent lack of health insurance benefits offered by low-paying employers.
The rest of the body of your paper will be made up of more major and minor points. Each major point should advance the paper’s central argument, often building on the previous points, until you have provided enough evidence and analysis to justify your paper’s conclusion.
More Major and Minor Points: In this paper, more major points might include mental health of high school dropouts, healthcare access for dropouts, and correlation between mental and physical health. Minor topics could include specific work environments, job satisfaction in various fields, and correlation between depression and chronic illness.
Conclusion
Your conclusion both restates your paper’s major claim and ties that claim into a larger discussion. Rather than simply reiterating each major and minor point, quickly revisit your thesis statement and focus on ending the paper by tying your thesis into current research in your field, next steps for other researchers, your broader studies, or other future implications.
Sample Conclusion: For this paper, a conclusion might restate the central argument (the link between lack of education and health issues) and go on to connect that discussion to a larger discussion of the U.S. healthcare or education systems.
WRITING ABOUT HISTORY
You should not approach this assignment as if you are creating a wikipedia page. Your Zine project must be an exercise in writing about history. What does this mean? It means that you should not simply recap your notes in a wiki-style straight forward presentation of facts. Writing about history is actually arguing a point of view or perspective. For this reason you need to push beyond simply recapping facts and tell us WHY these facts matter, WHAT these facts tell us about about American history and American pesent. Your Zine needs a point of view beyond, “this happened.” Your zine should also tell us why it is important that people know these facts. What are some potential pitfalls to not knowing these facts? Please pay attention to this part of the project. It is impossible to get an A on this assignment if you don’t adequately provide a perspective of the history you are presenting.

Discuss about substance abuse and addiction book review by Stephen Van Cleave.

This is a statistical Inference project. It requires Janovi to work the spreadsheet provided. I have the file but it is not a format that I am able to upload on here. Anyone still able to help??

Project Details
A. Select one of the datasets provided.
B. Create two hypotheses.
1. One must be able to be tested using a dependent means or paired samples t-test.
2. One must be able to be tested using an independent means and independent samples t-test.
C. Describe the variables used in your hypotheses.

1. Describe the variables in words.
2. Describe the variables numerically. For example, present measures of central tendency and variability (when appropriate) for the major variables.
3. Describe the variables graphically.
4. You should interpret these and not simply present the numbers.
5. Report demographic information of the sample, such as average age, percent of males and females.
6. Create a least one box plot, one histogram, and one frequency table. You should interpret these and not simply present the graphs/tables.

D. Test your hypotheses using the appropriate statistical procedure in Jamovi. For each hypothesis write a paragraph that states the statistics you ran and why. See the example below for details.

1. Write the results of what you found in APA style and provide relevant output at the end of the report.
2. State whether your results support or fail to support your hypothesis.

E. Create a report (approximately 2 – 5 pages) that combines what you completed and found in main bullet points B – D.
Example Write-up
Here is an example of what a write-up for a Chi-Square statistic might look like. Although this is not a template, this should help in formulating this report.
It was hypothesized that the number of people in my sample that liked cheese pizza would be greater than the number who liked anchovy pizza. To test this, a Chi—Square goodness of fit test was used. This test compares the observed frequency of categories in a single nominal/categorical variable, which is appropriate for comparing the frequency of pizza choice (the nominal/categorical variable) for the options of cheese or anchovy (the categories). A Chi-square goodness of fit test compared the frequency of cheese and anchovy pizza preference. We hypothesized that both would occur with equal frequency. A significant deviation from hypothesized values was found, χ2(1) = 25.92, p < .001. The observed frequency of preference for cheese (43) and anchovy (7) were significantly different from the expected frequency of each (25). This difference represents a large effect, ɸ = .72. These findings support our hypothesis, as significantly more people in our sample preferred cheese pizza (43) compared to anchovy pizza (7).

The goal of this assignment is to take the concepts learned in this course related to sociology (the knowledge) and apply them to a real-life scenario (application) after watching a film/movie that deals with humans and their interaction within society (connecting with the heart). There are no correct films (as long as it is a full-length film) and it reflects a range of sociological concepts discussed in class and within the course.
For instance, here are some great movies (my wife calls them “social work movies” as they deal with people and tug at your heartstrings) as examples:
I Am Sam
Radio
Glory Road
Remember the Titans
Space Cowboys
Devil Wears Prada
Social Network
Far and Away
Cinderella Man
Crazy Rich Asians
The Greatest Showman
Critique Instructions:
The film should be critiqued from a sociological viewpoint and answer the following questions:
How does the film depict U.S. society?
How accurate/realistic is this depiction?
What social influences do you see impacting the behavior of the major characters?
As you review the film, please bold the sociological concepts that you are identifying AND explain what part in the film made you stop and think” huh, that relates to what we discussed in class.” For instance, “As I was watching the movie, I observed that the main character, Joseph left the family farm and moved to the city where he obtained a job in a factory (concept of industrialization: people move from farm to city as society shifts from agrarian to industry). However, he was barely making ends meet (concept of social stratification: the poor stay poor at the profit of the rich) even working 70 hours a week.”
There should be a minimum of ten sociological concepts identified.
In terms of formatting, the paper needs to be 2 full pages in length and include the following components: introduction, body paragraphs, and conclusion. You all may choose between APA format [student face sheet, title, section headers, separate body paragraphs, summary/conclusion, and reference page] or MLA format (required information on the first page of content, title, summary/conclusion, and works cited page). Make sure to use in-text citations within the paper (give credit to the sources that were used within the paper to avoid plagiarism). In-text citations and a corresponding reference/work cited page are only needed if sources outside of the textbook are utilized in this assignment. Lastly, use 12 Times New Roman font and be double-spaced

Preliminary Considerations

First, one must understand that a critical book review is not a book report (a summary of the
contents of a book). A critical book review is a vehicle for examining and discussing issues the
book itself raises or fails to raise. One writes a critical book review for the benefit of those who
might not presently have time to read the book but who nevertheless need to learn more about
its basic approach should they desire to read or study it at a future time. The job of the book
reviewer is to inform these readers concerning any merits and/or shortcomings the book may
have. From information based on a well-written review, the reader may conclude that this book
is either indispensable or inconsequential.
Components of a Critical Book Review
A. Give complete bibliographical information at the top of the page (title, author, publisher,
place of publication, date of publication, number of pages, and name of reviewer).
Use the following format:
Toward Rediscovering the Old Testament, by Walter C. Kaiser, Jr. Grand
Rapids: Zondervan, l987. 250 pages. Reviewed by Randy C. Slocum.
B. Briefly state the reason this book was chosen for review. State the author’s credentials
(education, place of employment, previous achievements, etc.) as a preface to giving the book a
serious hearing. Biographical information about the author should be included only as it
demonstrates the author’s competency to write the book. Within the context of the paper, do
not use titles (Dr., Rev., etc.). In most brief reviews, you will likely need to limit the
introduction to one or two paragraphs.
C. Briefly (in one or two well-written sentences) summarize the thesis of the book.
This is a crucial step because the thesis contains the reason why the author produced this
particular book (there may be dozens on the market with similar subject matter).
The thesis will state the author’s basic presuppositions and approach. The critical nature of the
book review will then grow from the reviewer’s conclusion that the book does or does not
achieve the author’s stated purpose.
D. The main body of a critical book review will be concerned with “thesis development.”
That is, did the author achieve the stated purpose? In this section the reviewer will inspect each
of the chapters of the book to see how the thesis is (or is not) developed. If the author makes
progress and develops the thesis convincingly, providing adequate information and statistical
data, the reviewer says so, providing concrete examples and citing their page numbers in the
text.
Given the limited amount of space in a brief book review, footnotes should not
be utilized.

Quotations or ideas taken directly from the text should be followed
parenthetically by the page number of the quotation. The abbreviation for
page(s) (p./pp.) should not be used.
Example:
Rainer argues that evangelistic churches should focus on reaching youth (20).
Indeed, he writes, “Many churches fail to recognize that adolescence is a
critical time of receptivity to the
gospel” (21).
If the thesis is poorly developed or if the examples are inadequate to support
the assertions of the author, the reviewer will point this out as well. Most
critical book reviews will contain both praise and criticism, carefully weighed
and balanced against one another.
Remember the purpose of a critical book review is not to provide a summary
of the book. You may assume that the professor and the grader know the
contents of the book.
Questions the reviewer will seek to answer in this section might include:
• Is there an adequate, consistent development of the author’s stated thesis?
Why or why not?
• What is the author’s purpose, i.e., what does he/she hope to accomplish
through this book? Does the author accomplish the purpose? If so, how does
he/she do so? If not, why not?
• Does the author approach the subject with any biases, i.e., do the author’s
theological, experiential, philosophical, denominational, or cultural
perspectives influence his/her conclusions?
• Does the author properly support his/her thesis? Does the author adequately
consider and refute opposing viewpoints? Is the book limited in application to
specific types of churches? Is the book relevant to contemporary culture?
• Does the author have to resort to suppression of contrary evidence in order to
make the thesis credible (slanting)? If so, what additional evidence would
weaken the case?
• Is the thesis sound but marred by a flawed procedure?
• Is the author’s case proved, or would another thesis have been more
appropriately chosen?
E. Finally, a summary section should be attached. How does this book differ from other
treatments of the same subject matter? What is unique and valuable about this approach as
opposed to the others? Would the reviewer recommend this book above others? Why or why
not?
This final summary should include the major strengths and weaknesses of the
book and evaluate its value for readers who may be interested in that particular
field of inquiry. Your primary purpose in this section is to respond both
positively and negatively to the book’s contents and presentation. Needless to
say, this response should be more in-depth than, “This book is a good book
that should be recommended reading for everyone.” On the other hand,

“This book is a lousy book not worth reading” is also inadequate. Central to
this is the basic question of whether or not the author has achieved the book’s
stated purpose.
Answer questions such as:
• What are the strengths of the book, i.e., what contributions does the book
make?
• Why should a person read this book?
• What did you learn from this book?
• How might you apply the lessons of this book in your ministry context?
• Would you recommend the book to other ministers? To seminary students?
To laypersons? Why, or why not?
Do not allow your response to this question to become lengthy (for this paper
is not primarily an evaluation of your ministry), but do make some application.
Throughout your critique, be specific in your evaluations. Do not just tell the
reader about the book; tell and show the reader with concrete examples from
the book. As previously suggested, include page numbers when making
specific reference to the book.
F. The length of the review should be between 3 and 4 pages, double-spaced using Times New
Roman 12-Point font.
Style Issues for a Critical Book Review
Turabian’s A Manual for Writers of Term Papers, Theses, and Dissertations (7th ed.) is the
accepted standard for style issues.
The following guidelines are included to counter common style errors:
A. Utilize this suggested outline to guide your book review, but do not include the specific
subheadings (“Bibliographical Entry,” “Summary of the Book,” etc.) in the essay. The brevity of
the review demands a smooth flow from one section to another without including the
subheadings.
B. Use first-person sparingly; however, you may use “I” when referring to your opinion of a text.
C. Avoid contractions in formal writing.
D. Use active voice as much as possible.
E. Be clear and concise. A brief review allows no room for wandering from your objective.

* Explain each variable in the file that you are analyzing. Be sure your file includes at least 3 scale variables and at least 2 nominal variables.
* Conduct a descriptive analysis on any 2 interval / ratio variables you wish using Descriptive_Statistics.xls and Frequency_Distribution.xls. Explain the output.
* Conduct 3 different hypothesis tests of your choice using appropriate variables from the file (note: you must use 3 different tests and not run one test on 3 different variables). In each case, state the variables being tested as well as the hypothesis, decision and conclusion. Use 3 of the following (1-Sample Test for Means, 1-Sample Test for Proportions, 2-Sample Test for Means – Independent Samples, 2-Sample Test for Means – Paired Samples, 2-Sample Test for Proportions, Analysis of Variance, Chi Square Goodness of Fit Test, Chi Square Test of Independence, Correlation Test).
* Develop a model to predict an interval / ratio variable using at least 2 other variables. Use Multiple_Regression.xls and state the regression model and which variables are or are not significant. Also, use the model to make a prediction by making up values for each of the independent variables.
* Write a one to two page summary of your findings. Include the data file in the appendix.