Explain how anatomical and physiological changes impact digestive pathology presentation? What is the link between digestion and psychology? In this discussion we will explore both concepts, as interest in both managing digestive disorders and psychological presentations represent growing fields.
Initial Post
Read the introduction, conclusion, and one section regarding a condition that piques your interest in Intestinal epithelial barrier and neuromuscular compartment in health and disease.
Focus on the general concepts, as opposed to understanding every word. After completing the reading, answer the following question for your initial post: “How does digestive physiology lead to a specific pathological presentation?” You may choose which digestive pathology you’d like to focus on.
Use the assigned article, with appropriate APA citations, to support your position with at least 5-6 sentences to support your case.
Reply Post
In your reply post, share what factors you find most surprising, as well as any experiences and questions you have about digestive system physiology and pathology presentation. You may use the assigned article, or other credible references of your own selection to support your follow-up post(s).
POST to reply to:
11/10/21, 10:13 PM
NEW
The topic I choose to focus on is Neuropsychiatric disorders within the morphological features of IEB and neuromuscular compartment in extra-digestive diseases subject. Individuals with neuropsychiatric diseases like PD, AD, ALS, MS, ASD, and depression are generally characterized by functional digestive problems such as infrequent bowel movements, abdominal distention, and constipation (D’Antongiovanni et al., 2020). Evidence indicates changes in gut microbiota composition, IEB impairments, intestinal inflammation, as well as enteric neuromuscular compartment rearrangements contribute to bowel motor dysfunctions (D’Antongiovanni et al., 2020). An increase in IEB permeability and decreased colonic ZO-1 expression with severe intestinal symptoms in PD patients have been observed, insinuating that IEB morphofunctional alterations can contribute to bowel motor dysfunction in PD (D’Antongiovanni et al., 2020). Evidence of intestinal permeability changes in people with MS and ASD have been documented and the respective patterns have shown a correlation of disability status (D’Antongiovanni et al., 2020). Evidence indicates that individuals with CNS diseases have shown alterations of enteric neuromuscular compartment, insinuating bowel dysmotility contribution (D’Antongiovanni et al., 2020). How does digestive physiology lead to a specific pathological presentation? According to D’Antongiovanni et al. (2020), “changes in TJ protein expression and distribution as well as morphofunctional alterations of EGCs represent a common feature of such disorders, that could contribute to the pathophysiology of bowel motor disturbances.”
References
D’Antongiovanni, V., Pellegrini, C., Fornai, M., Colucci, R., Blandizzi, C., Antonioli, L., & Bernardini, N. (2020). Intestinal epithelial barrier and neuromuscular compartment in health and disease. World journal of gastroenterology, 26(14), 1564–1579. https://doi.org/10.3748/wjg.v26.i14.1564
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