1. Answer the following questions: (11 pts total)
a. List and explain the steps of T cell activation downstream of TCR that lead to activation of NFAT and NF-κB. (6 pts)
b. Predict what would occur in T cells deficient in PLC-g? (2 pts)
c. Design an experiment to provide evidence for your prediction in part b. of this question. (3 pts)
2. Describe how the individual components of the BCR co-receptor function to promote B cell activation. (6 pts)
3. Answer the following questions: (8 pts total)
a. Describe how intestinal macrophages
function differently than non-mucosal macrophages. (4 pts)
b. Design an experiment to provide evidence for your answer in part a. of this question. (4 pts)
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