What are your thoughts on the ability of a single nucleotide mutation to cause such effects on an entire organism ?

After viewing the video and reading the case study on Sickle cell anemia, comment on the ability of a single nucleotide mutation to cause such effects on an entire organism.
What are your thoughts on the ability of a single nucleotide mutation to cause such effects on an entire organism ? Why? Name two other diseases that are caused by a point mutation. (Click link below)

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