What is the importance of onset of effects and duration of action in terms of abuse potential and withdrawal symptoms?

What is the importance of onset of effects and duration of action in terms of abuse potential and withdrawal symptoms? How do these principles inform our understanding of the relative danger of different classes of sedatives (e.g., barbiturates versus benzodiazepines)?
If opioid-related chronic toxicity were not a problem, would opioid addiction be a societal problem? What do you think of treating a heroin addict with daily doses of another opioid (such as methadone)? Would it be appropriate to treat that patients addiction with heroin? Why or why not?

Requirements:
– 1 scholarly source required (Use information that support your answer)
– more than 350 words
– use lectures if possible too please (attachment)
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