Session 7 Case Study
Read the case study and review the resources before completing the questions. Record your answers on a Word Document and include references in APA format for the resources you use to answer the assigned questions. This assignment is worth 15 points.
Chronic Myelogenous Leukemia (CML)
A 58-year-old woman is being treated for CML. She has done a lot of reading and has some questions about her chemotherapy. She is being treated with a tyrosine kinase inhibitor called Gleevec (also known as Imatinib). She has a friend who comes in for treatment at the same time who also has CML but is not receiving that drug. She is concerned about the different drug choices. Your patient is Philadelphia chromosome positive, but her friend is not.
For background information, review A Glimpse of History on page 385 and Figure 20.12 in your textbook. You may also wish to review the following websites:
Chronic Myelogenous Leukemia Resources
U.S. National Library of Medicine. (2020). Chronic Myeloid Leukemia. MedlinePlus.
https://medlineplus.gov/genetics/condition/chronic-myeloid-leukemia/#genes
National Cancer Institute. (2020). Chronic Myelogenous Leukemia Treatment – Patient Version.
https://www.cancer.gov/types/leukemia/patient/cml-treatment-pdq
National Organization for Rare Disorders. (2018). Chronic Myelogenous Leukemia.
American Society of Clinical Oncology. (2021). Leukemia – Chronic Myeloid – CML.
http://www.cancer.net/cancer-types/leukemia-chronic-myeloid-cml
National Cancer Institute. (2021). Chronic Myelogenous Leukemia Treatment – Health Professional Version.
https://www.cancer.gov/types/leukemia/hp/cml-treatment-pdq
John Hopkins University’s Online Mendelian Inheritance in Man. (2019). Leukemia, Chronic Myeloid; CML, OMIM#608232.
http://omim.org/entry/608232
After familiarizing yourself with CML, concisely answer the following questions:
What chromosomal mutation is typically observed in CML patients and what is the name of the new oncogene created by this mutation? (3 pts)
Which protein does this oncogene overproduce and how does this abnormal protein lead to the development of cancer? (5 pts)
Is CML inherited? (2 pts)
After assessing each patient in the case study, how would you explain the difference in their chemotherapeutic regimens to your patient? (5 pts)
To avoid plagiarism, do not copy/paste answers directly from the resources. Rather, summarize answers in your own words. Remember to appropriately cite and reference resources according to APA standards.
Click on the Session 7 Case Study link to submit your assignment by the posted due date.
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