Write a literature review of sickle cell anemia including its embryology, anatomy, biochem, histology, physiologym and genetic background.

Write a literature review of sickle cell anemia including its embryology, anatomy, biochem, histology, physiologym and genetic background. Should also include info on the epidemiology, pathophysiology/physiology, clinical manifestations, diagnosis/differential diagnosis, treatment, prevention, and new developments.

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